By Peter A. McCullough, MD, MPH | Brave Discourse

In my apply, most sufferers with post-acute sequelae after SARS-CoV-2 an infection and COVID-19 vaccination are on the McCullough Protocol Base Spike Cleansing: nattokinase, beginning dose 2000 items twice a day; bromelain, 500 milligrams a day; and curcumin, 500 milligrams twice a day. The phrase “base” is necessary as a result of it signifies that along with triple remedy with nattokinase, bromelain, and curcumin, different medicine and interventions might be added to scale back the depth and length of signs whereas the foundation explanation for the syndrome (Spike protein) is being cleared from the physique.

Leitzke summarized the literature on post-acute sequelae being associated to residual SARS-CoV-2 interactions with the ACE-2 receptor in addition to nicotinic acetylcholine receptors (nAChR).

Changeux et al. (2020) just lately proposed a ´nicotine speculation´, which implicates the propensity of SARSCoV-2 to not solely bind to ACE2-receptors (ACE2R) however to nicotinic AChRs, as properly (Changeux et al. 2020). Viral particles competing with acetylcholine for nAChR binding so as to enter the human physique could result in major neuro an infection (Changeux et al. 2020; Steardo et al. 2020). Moreover, among the many extreme and deadly circumstances of COVID-19, the proportion of nicotine shoppers was considerably decrease than non-consumers of nicotine (Miyara, et al. 2020). Since nicotine could shield nAChRs from viral attachment, therapeutic nicotine utility was proposed within the administration of acute COVID-19 infections (Changeux et al. 2020). This argument is convincingly supported by the cohort examine of Hippisley-Cox et al. (2020), with a complete of 8.28 million contributors (together with 19,486 confirmed COVID-19 circumstances), displaying decrease odds for COVID-19 an infection and COVID-19-related ICU keep in affiliation with smoking (Hippisley-et al. 2020).

Nicotine binds to nAChR and works to competitively antagonize Spike protein whereas on the similar time upregulating nAChR.

Is the post-COVID-19 syndrome a extreme impairment of acetylcholine-orchestrated neuromodulation that responds to nicotine administration?

“From a scientific perspective, nicotine utility results in purposeful enchancment of vigilance, locomotor exercise, cognition, respiratory operate, cortical blood circulation, EEG exercise and ache resilience, in addition to gastrointestinal and cardiovascular regulation in animals (Lloyd and Williams 2000). French et al. (1999) demonstrated a long-lasting (as much as 72 h after nicotine publicity) improve of neurotrophic nerve development issue (NGF) mRNA after nicotine administration to the hippocampus, suggesting long-term neuroprotective results of nicotine (French et al. 1999). Nicotine works as a ligand with excessive affinity and profound intrinsic exercise on nAChRs (Gottiet al. 2006), enhancing the responsiveness (Buisson and Bertrand 2001) and exercise (Lloyd and Williams 2000) of those core receptors of neuromodulation considerably.”

Leitzke presents 4 circumstances of primarily younger individuals with long-COVID syndrome handled with nicotine patches 7.5 to fifteen mg/24 with documented enchancment in a number of domains together with neurological, cognitive, cardiovascular, and normal well-being. I’ve had a number of sufferers inform me “mind fog” and normal lassitude improves with using nicotine patches. We can not make any therapeutic claims since massive, potential, double-blind, placebo-controlled randomized trials haven’t been carried out with nicotine. Nevertheless the rationale and empirical proof seems robust and would help future trials.

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